・Takeda Y*., Matsuguchi S*., Nozaki S., Mihara T., Abe J., Hirai Y. (2022). Suppression of P-cadherin expression as a key regulatory element for embryonic cell stemness. Cell Struc. Funct. In press. https://doi.org/10.1247/csf.22060

・Hori H., Kotani A., Abe J., Matsuguchi S., Hirai Y. (2022). Extracellular epimorphin impairs expression and processing of profilaggrin in HaCaT keratinocytes. Cytotechnology in press. https://doi.org/10.1007/s10616-022-00566-8

・Shono, M., Kadono,N., Miyazaki,T., Hirai, Y. (2013). Ectopic expression of syntaxin3 affects behaviors of B16 melanoma by controlling actin dynamics. Cell Struc. Funct.  in press  [doi: 10.1247//csf.12032]

・Okugawa, Y., Hirai, Y. (2013). 　Extracellular epimorphin modulates epidermal differentiation signals mediated by epidermal growth factor receptor. J Dermatol. Sci. 69, 236-242.

・Takase T, Hirai Y (2012). Identification of the C-terminal tail domain of AHF/Trichohyalin as the critical site for modulation of the keratin filamentous meshwork in the keratinocyte. J. Dermatol. Sci.in press　(DOI 10.1016/j.jdermsci.2011.12.014)

・Kadono N, Miyazaki T, Okugawa Y, Nakajima K,Hirai Y (2012). The impact of extracellular syntaxin4 on HaCaT keratinocyte behavior.  Biochem. Biophys. Res. Commun.inpress (DOI 10.1016/j.bbrc.2011.12.107)

・Aono Y, Hirai Y (2011). A culture system for the live analysis of successive developmental processes and the morphological control of mammalian vertebral cartilage. Cytotechnology 63,269-77.

・Kinoshita N, Horie Y, Ohshima S, Hirai Y., Dohmen T, Jin M, Matsuhashi T, Sasaki J, Sasaki T, Iizuka M, Ohnishi H. (2011). Epimorphin protects hepatocytes from oxidative stress by inhibiting mitochondrial injury. J Gastroenterol Hepatol. 26:201-6.

・Okugawa Y, Bascom J, Hirai Y.(2010) Epimorphin-derived peptides remedy epidermal parakeratosis triggered by unsaturated fatty acid. J. Derm. Sci. 59 176-183

・Yamada M, Oda T, Higashi K, Kushiyama T, Yamakami K, Hirai Y, Yamamoto K, Hyodo T, Suzuki S, Miura S,Kumagai H.(2010)  Involvement of epimorphin in the repair of experimental renal fibrosis in mice.  Lab Invest. 90:867-880.

･Radisky DC, Stallings-Mann M, Hirai Y and Bissell MJ.(2009)  Single proteins serve multiple functions in intracellular and extracellular environments Nat.Rev. Mol. Cell Biol. 10:　228-234.

・Chen CS, Nelson CM, Khauv D, Bennett S, Radisky ES, Hirai Y, Bissell MJ, Radisky DC.(2009)  Homology with Vessicle Fusion Mediator Syntaxin-1a Predicts Determinants of Epimorphin/Syntaxin-2 Function in Mammary Epithelial Morphogenesis.  J. Biol. Chem.284:　6877-6884.

・Aono S., Hirai Y. (2008）　 Phosphorylation of claudin-4 is required for tight junction formation in a human keratinocyte cell line. Exp. Cell Res. 2008 314:3326-3339

･Yamamoto S., Hirai K., Hasegawa-Oka Y., Hirai Y. (2008) Molecular elements of the regulatory control of keratin filament modulator AHF/Trichohyalin in the hair follicle. Exp Dermatol. 2008 18:152-159

･Okugawa Y., Hirai Y. (2008) Overexpression of extracellular epimorphin leads to impaired epidermal differentiation in HaCaT keratinocytes. J. Invest. Dermatol. 128:1884-1893.

･Miura K., Yoshino R.,, Hirai Y., Goto T., Ohshima S., Mikami K., Yoneyama K., Watanabe D., Sato M., Senoo H., Kodama Y., Osawa Y., Brenner D.A., Watanabe S. (2007) Epimorphin regulates spheroid formation by inducing proteases in rodent hepatocytes through NF-κB J. Hepatology. 47: 834-843.

･Hirai Y., Bissell M.J., Radisky D.C. (2007) Extracellular localization of epimorphin/syntaxin-2. Blood. 110: 3082.

･Hirai Y.,Nelson C.M., Yamazaki K., Takebe K., Przybylo J., Madden B., Radisky DC. (2007) Non-classical export of epimorphin and its adhesion to αv-integrin in regulation of epithelial morphogenesis. J Cell Sci. 120:2032-43.
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･Iizuka M., Sasaki K., Hirai Y., Shindo K., Konno S., Itou H., Ohshima S., Horie Y., Watanabe S. (2007) Morphogenic protein epimorphin protects intestinal epithelial cells from oxidative stress by the activation of EGF receptor and MEK/ERK, PI3 kinase/Akt signals. Am J Physiol Gastrointest Liver Physiol. 292:G39-52.
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･Otani T., Ichii T., Aono S., Takeichi M. Cdc42 GEF Tuba regulates the junctional configuration of simple epithelial cells.
J Cell Biol. 2006 Oct 9;175(1):135-46. Epub 2006 Oct 2.

･Yoshino R.., Miura K. ,Segawa D., Hirai Y., Goto T., Ohshima S., Mikami K.I.., Yoneyama K., Shibuya T., Watanabe D., Kataoka E.,　Takeuchi S., Endoh A., Sato W., Watanabe S. (2006)　Epimorphin expression and stellate cell status in mouse liver injury.Hepatol Res. 34:238-249

・Tulachan S.S., Doi R.., Hirai Y.,Kawaguchi Y., Koizumi M., Hembree M., Tei E., Crowley A., Yew H. ,McFall C., Prasadan K., Preuett B., Imamura M., and Gittes G.K. (2006)　Mesenchymal epimorphin is important for pancreatic duct morphogenesis. Develop.Growth Differ. 48:65-72

･Oka,Y., Sato Y., Tsuda H., Hanaoka K., Hirai Y.,and Takahashi Y., (2006)　Epimorphin acts extracellularly to promote cell-sorting and aggregration during the condensation of vertebral cartilage. Dev.Biol. 291:25-37

･Bascom J.L., FataJ.E., Hirai Y., Sternlicht M.D., and Bissell M.J. (2005) Epimorphin overexpression in the mouse-mammary gland promotes alveolar hyperplasia and mammary adenocarcinoma. Cancer Res. 65, 8617-8621

･Hirai Y., Takebe K., and Nakajima K., (2005). Structural optimization of pep7, a small peptide extracted from epimorphin, for effective induction of hair follicle anagen. Exp. Dermatol 14,692-699

・Qin J., Takahashi, Y., Isuzugawa, K., Imai, M., Yamamoto S., Hirai Y., and Imakawa K. (2005) Regulation of embryo outgrowth by a morphogenic factor, epimorphin, in the mouse. Mol Reproduction and Development. 70:455-63

・ Aono S., Legouis, R., Hoose, W.A., and Kemphues, K.J. (2004) PAR-3 is required for epithelial cell polarity in the distal spermatheca of C. elegans. Development 131, 2865-2874
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・Andoh, A., Fujino, S., Hirai Y., and Fujiyama, Y. (2004) Epimorphin expression in human colonic myofibroblasts Int. J. Mol. Med. 13, 57-61

・Takebe, K., Oka,Y., Radisky, D., Tsuda, H., Tochigui, K., Koshida, S., Kogo, K. and Hirai Y. (2003) Epimorphin acts to induce hair follicle anagen in C57BL/6 mice. FASEB J. 17, 2037-2047
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・Radisky, D,Hirai Y., and Bissell, M.J. (2003) Delivering the message: epimorphin and mammary epithelial morphogenesis TRENDS Cell Biol. 13, 426-434

・ Shirasaka T., Iizuka M., Yukawa, M.,Hirai Y., Horie Y., Itou H., Kom-no S., Fukushima T. and Watanabe S. (2003) Altered expression of epimorphin in ulcerative colitis. J. Gastro. Hepatol. 18, 570-577

・ Simian, M., Hirai Y., Nerve, M., Werb, Z., Lochter, A. and Bissell, M.J. (2001).　The interplay of matrix metalloproteinases, morphogen and growth factors is necessary for branching of mammary epithelial cells Development 128, 3117-3131

・Hirai Y., Radisky, D., Boudreau, R., Simian, M., Stevens M.E., Oka,Y., Takebe K., Niwa S. and Bissell M.J. (2001). Epimorphin mediate mammary luminal morphogenesis through control of C/EBPb J. Cell Biol. 153, 785-794
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・ Lehnert, L., Lerch, MM., Hirai Y., Kruse M.L., Schmiegel W., and Kalthoff H. (2001). Autocrine stimulation of human pancreatic duct-like development by soluble isoform of epimorphin J. Cell Biol. 152, 911-921

・Hirai Y. (2001)　Epimorphin as a morphogen: does a protein for intracellular vesicular targeting act as an extracellular signaling molecule? Cell Biol. Int. 25, 193-195

・Aono S.,Nakagawa S., Reynolds, A.B., and Takeichi M (1999) p120ctn acts　as an inhibitory regulator of cadherin function in coloncarcinoma cells. J. Cell Biol. 145, 551-562
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・Hirai Y., Lochter A., Galosy, S., Koshida, S., Niwa, S. and Bissell, M.J. (1998).　Epimorphin functions as a key morphoregulator for mammary epithelial cells J. Cell Biol. 140, 159-169
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・Koshida, S and Hirai Y. (1997).　Identification of cellular recognition sequence of epimorphin and critical role of cell/epimorphin interaction in lung branching morphogenesis Biochem. Biophys. Res. Commun. 234,522-525

・Oka,Y. and Hirai Y. (1996)　Inductive influences of epimorphin on endothelial cells in vitro. Exp. Cell Res. 222, 189-198

・Hirai Y. (1994) Sodium-dodecyl-sulfate-resistant complex formation of epimorphin monomers and
interaction of the 150KDa complex with the cell surface　Eur.J. Biochem. 225, 1133-1139

・ Hirai Y., Nakagawa S., and Takeichi M., (1993)　Reexamination of properties of epimorphin and its possible roles Cell 73, 426-427

・Hirai Y. (1993) Molecular cloning of human epimorphin; Identification of isoforms and their unique properties　Biochem. Biophys. Res. Commun. 191, 1332-1337

・ Hirai Y., Takebe, K., Takashina, M. Kobayashi, S. and Takeichi, M. (1992)　 Epimorphin: A mesenchymal protein essential for epithelial morphogenesis　Cell 69, 471-481

・ Hirai Y., Takebe, K., Nakajima, M. Takashina, M. and Iizuka, M. (1991) Extended expression of liver functions of hepatocytes in collagen-contained cell aggregates (cell packs)　Cytotechnology 6, 209-217

・Hirai Y., Nose, A., Kobayashi, S. and Takeichi, M. (1989)　Exprtession and role of E- and P-cadherin adhesion molecules in embryonic histogenesis II. Skin morphogenesis　Development 105, 271-277

・Hirai Y., Nose, A., Kobayashi, S. and Takeichi, M. (1989)　Exprtession and role of E- and P-cadherin adhesion molecules in embryonic histogenesis I. Lung epithelial morphogenesis Development 105, 263-270

・Kitano H., Nakamura K., Hirai Y. Kaku T., Ise N.　(1988） Restricted diffusion effect on the binding of proteins to porous polymer resins as studied by repetitive injection method. Biotechnology and Bioengineering 31:547-552.

・Kitano H.,Hirai Y. Okada Y, Nakamura K., Ise N. (1987) Pulse injection analysis of the binding of serum proteins to porous polymer gels modified with formyl groups. J Chromatogr. 420:13-24.

・Nakamura K.,Hirai Y. Kitano H., Ise N. (1987) Dynamic analysis of irreversible adsorption of protein on porous polymer resins as studied by pulse injection method. Biotechnology and Bioengineering 30:216-224.

・Kitano H., Hirai Y., Nakamura K., Ise N. (1986) Assay of enzyme activities and low-molecular-mass constituents in serum using stopped-flow technique coupled with gel-permeation chromatography. J Chromatogr 383:229-231.

・Nakamura K., Hirai Y., Kitano H. (1985) Binding of serum proteins to polymer gels. II. Binding mechanism to polyoxyphenol-formaldehyde gels. J Appl Biochem 7:145-154.