Original papers

Shibata, Y., Tanaka, Y., Sasakura, H., Morioka, Y., Sassa, T., Fujii, S., Mitsuzumi, K., Ikeno, M., Kubota, Y., Kimura, K., Toyoda, H., Takeuchi, K., and Nishiwaki, K. (2024). Endogenous chondroitin extends the lifespan and healthspan in C. elegans.
Sci. Rep. 14(1): 4813

Tsutsui, K., Kim, H., Yoshikata, C., Kimura, K., Kubota, Y., Shibata, Y., Tian, C., Liu, J., and Nishiwaki, K.(2021).Repulsive guidance molecule acts in axon branching in Caenorhabditis elegans..
Sci. Rep.　11(1):22370.

Imanishi, A ., Aoki, Y., Kakehi, M., Mori, S., Takano, T., Kubota, Y., Kim, H-S., Shibata, Y.,. and  Nishiwaki, K. (2020). Genetic interactions among ADAMTS metalloproteases and basement membrane molecules in cell migration in Caenorhabditis elegans.
PLoS One 15(12):e0240571.

Kubota,Y.,Nishiwaki, K., Ito, M. and Sugimoto, A.(2019) The Role of Tissue Inhibitors of Metalloproteinases in Organ Development and Regulation of ADAMTS Family Metalloproteinases in Caenorhabditis elegans
Genetics 212:523-535.

Shibata, Y., Seki, Y. and Nishiwaki, K. (2018). Maintenance of cell fates and regulation of the histone variant H3.3 by TLK kinase in Caenorhabditis elegans.
Biol. Open bio.038448.

Ishii, T., Funato, Y., Hashizume, O., Yamazaki, D., Hirata, Y., Nishiwaki, K., Kono, N., Arai, H. and Miki, H. (2016). Mg2+ extrusion from intestinal epithelia by CNNM proteins is essential for gonadogenesis via AMPK-TORC1 signaling in Caenorhabditis elegans.
PLoS Genetics 12(8): e1006276.

Shibata, Y., Kawakado,Y., Hori,N., Tanaka, K., Inoue, R., Takano, T., Kubota, Y., Nishiwaki,K.(2016). Organ Length Control by an ADAMTS Extracellular Protease in Caenorhabditis elegans.
G3(Bethesda). 6: 1449-1457.

Kikuchi, T., Shibata, Y., Kim, H.-S., Kubota, Y., Yoshina, S., Mitani, S. and Nishiwaki, K. (2015). The BED finger domain protein MIG-39 halts migration of distal tip cells in Caenorhabditis elegans.
Dev. Biol. 397: 151-161.　

Huang, T-F., Cho, C-Y., Cheng, Y-T., Huang, J-W., Wu, Y-Z., Yeh, A. Y-C., Nishiwaki, K., Chang, S-C., and Wu, Y-C. (2014). BLMP-1/Blimp-1 Regulates the Spatiotemporal Cell Migration Pattern in C. elegans.
PLoS Genetics 10(6): e1004428.　

Kim, H-S., Kitano, Y., Mori, M., Takano, T., Harbaugh, T. E., Mizutani, K., Yanagimoto, H., Miwa, S., Ihara, S., Kubota, Y., Shibata, Y., Ikenishi,K., Garriga, G., and Nishiwaki, K. (2014). The novel secreted factor MIG-18 acts with MIG-17/ADAMTS to control cell migration in Caenorhabditis elegans.
Genetics 196: 471-479.　

Shibata, Y., Sawa, H., and Nishiwaki, K. (2014). HTZ-1/H2A.z and MYS-1/MYST HAT act redundantly to maintain cell fates in somatic gonadal cells through repression of ceh-22 in Caenorhabditis elegans.
Development 141: 209-218.　

Doi, M., Minematsu, H., Kubota, Y., Nishiwaki, K., and Miyamoto, M. (2013). The novel Rac effector RIN-1 regulates neuronal cell migration and axon pathfinding in C. elegans.
Development 140: 3435-3444.　

Kubota, Y., Nagata, K., Sugimoto, A., and Nishiwaki, K. (2012). Tissue Architecture in the Caenorhabditis elegans Gonad Depends on Interactions among Fibulin-1, Type IV Collagen and the ADAMTS Extracellular Protease.
Genetics 190: 1379-1388　

Shibata, Y., Uchida, M., Takeshita, H., Nishiwaki, K., and Sawa, H. (2011). Multiple functions of PBRM-1/Polybromo- and LET-526/Osa-containing chromatin remodeling complexes in C.elegans development.
Dev Biol.　361: 349-357　

Kim, H.-S., Murakami, R., Quintin, S., Mori, M., Ohkura, K., Tamai, K., Labouesse, M., Sakamoto, H., and Nishiwaki, K. (2011). VAB-10 spectraplakin acts in cell and nuclear migration in Caenorhabditis elegans. Development 138: 4013-4023. 　　
この論文はFaculty of 1000 (F1000)によって、生物学・医学分野論文の上位２％に選ばれました。 http://f1000.com/13078957

Ogawa, H., Shionyu, M., Sugiura, N., Hatano, S., Nagai, N., Kubota, Y., Nishiwaki, K., Sato, T., Gotoh, M., Narimatsu, H., Shimizu, K., Kimata, K. and Watanabe, H. (2010). Chondroitin sulfate synthase-2/chondroitin polymerizing factor has two variants with distinct function.
J Biol Chem. 285: 34155-34167.

Kawano, T., Zheng, H., Merz, D. C., Kohara, Y., Tamai, K. K., Nishiwaki, K. and Culotti, J. G. (2009). C. elegans mig-6 encodes papilin isoforms that affect distinct aspects of DTC migration, and interacts genetically with mig-17 and collagen IV.
Development 136: 1433-1442.

Kubota, Y., Ohkura, K., Tamai, K. K., Nagata, K. and Nishiwaki, K. (2008). MIG-17/ADAMTS controls cell migration by recruiting nidogen to the basement membrane in C. elegans.
Proc. Natl. Acad. Sci. USA 105: 20804-20809.

Ihara, S. and Nishiwaki, K. (2008). Stage-specific activation of MIG-17/ADAMTS controls cell migration in Caenorhabditis elegans .
FEBS J. 275: 4296-4305.

Tamai, K. K. and Nishiwaki, K. (2007). bHLH transcription factors regulate organ morphogenesis via activationof an ADAMTS protease in C. elegans.
Dev. Biol. 308: 562-571.

Ihara, S. and Nishiwaki, K. (2007). Prodomain-dependent tissue targeting of an ADAMTS protease controls cell migration in Caenorhabditis elegans.
EMBO J. 26: 2607-2620.

Takasaki, T., Liu, Z., Habara, Y., Nishiwaki, K., Nakayama, J., Inoue, K., Sakamoto, H. and Strome, S. (2007). MRG-1, an autosome-associated protein, silences X-linked genes and protects germline immortality in C.elegans.
Development 134: 757-767.

Suzuki, N., Toyoda, H., Sano, M. and Nishiwaki, K. (2006). Chondroitin acts in the guidance of gonadal distal tip cells in C. elegans.
Dev. Biol. 300: 635-646.

Reiner, D. J., Weinshenker, D., Tian, H., Thomas, J. H., Nishiwaki, K., Miwa, J., Gruninger, T., Leboeuf, B. and Garcia, L. R. (2006). Behavioral genetics of Caenorhabditis elegans unc-103-encoded erg-like K(+) channel.
J. Neurogenet. 20: 41-66.

Rottiers, V., Motola, D. L., Gerisch, B., Cummins, C. L., Nishiwaki, K., Mangelsdorf, D. J. and Antebi A. (2006) Hormona l Control of C. elegans. Dauer Formation and Life Span by a Rieske-like Oxygenase.
Dev. Cell 10: 1-10.

Kubota, Y., Sano, M., Goda, S., Suzuki, N. and Nishiwaki, K. (2006). The conserved oligomeric golgi complex acts in organ morphogenesis via glycosylation of an ADAM protease in C. elegans.
Development 133: 263-273.

Itoh, B., Hirose, T., Takata, N., Nishiwaki, K., Koga, M., Ohshima, Y. and Okada, M(2005). SRC-1, a non-receptor type of protein tyrosine kinase, controls the direction of cell and growth cone migration in C. elegans.
Development. 132: 5161-5172.

Kubota, Y., Kuroki, R., and Nishiwaki, K. (2004). A fibulin-1 homolog interacts with an ADAM protease that controls cell migration in C. elegans.
Current Biology 14: 2011-2018.
この論文はFaculty of 1000 (F1000)によって、生物学・医学分野論文の上位２％に選ばれました。 http://f1000.com/13078957

Nishiwaki, K., Kubota, Y., Chigira, Y., Roy, S. K., Suzuki, M., Schvarzstein, M., Jigami, Y., Hisamoto, N. and Matsumoto, K. (2004). An NDPase links ADAM protease glycosylation with organ morphogenesis in C. elegans.
Nat. Cell Biol. 6: 31-37.
この論文はFaculty of 1000 (F1000)によって、生物学・医学分野論文の上位２％に選ばれました。 http://f1000.com/13078957

Gumienny, T. L, Brugnera, E., Tosello-Trampont,A.-C., Kinchen, J. M., Haney,L. B., Nishiwaki, K., Walk, S. F., Francis,R., Schedl, Y. Q., Van Aelst, L., Hengartner, M. O. and Ravichandran, K. S.(2001). CED-12/ELMO, a novel member of the CRKII/DOCK180/RAC pathway, is required for phagocytosis and cell migration.
Cell 107: 27-41.

Suzuki, N., Buechner, M., Nishiwaki. K., Hall, D. H., Nakanishi, H., Takai, Y., Hisamoto, N. and Matsumoto, K. (2001).  A putative GDP-GTP exchange factor is required for development of the excretory cell in C. elegans.
EMBO Reports 21: 530-535.

Nishiwaki, K. and Miwa, J. (2001). emb-1 and emb-3 genes are required for post-fertilization meiosis in Caenorhabditis elegans.
Jpn. J. Nematol. 31: 12-18.

Nishiwaki, K., Hisamoto, N., and Matsumoto, K. (2000). A metalloprotease distintegrin that controls cell migration in Caenorhabditis elegans.
Science 288: 2205-2208.

Nishiwaki, K. (1999). Mutations affecting symmetrical migration of distal tip cells in Caenorhabditis elegans.
Genetics 152: 985-997.

Nishiwaki, K., and Miwa, J. (1998). Mutations in genes encoding extracellular matrix proteins suppress the emb-5 gastrulation defect in Caenorhabditis elegans.
Mol. Gen. Genet. 259: 2-12.

Sano, T., Tabuse, Y., Nishiwaki, K. and Miwa, J. (1995). The tpa-1 gene of Caenorhabditis elegans encodes two proteins similar to Ca2+-independent protein kinase Cs: Evidence by complete genomic and complementary DNA sequences of the tpa-1 gene.
J. Mol. Biol. 251: 477-485.

Tabuse, Y., Sano, T., Nishiwaki, K. and Miwa, J. (1995). Molecular evidence for the direct involvement of a protein kinase C in developmental and behavioral susceptibility to tumor-promoting phorbol esters in Caenorhabditis elegans.
Biochem. J. 312: 69-74.

Nishiwaki, K., Sano, T.. and Miwa, J. (1993). emb-5, a gene required for the correct timing of gut precursor cell division during gastrulation in Caenorhabditis elegans, encodes a protein similar to the yeast nuclear protein SPT6.
Mol. Gen. Genet. 239: 313-322.

Gengyo-Ando, K., Kamiya, Y., Yamakawa, A., Kodaira, K., Nishiwaki, K., Miwa, J., Hori, I. and Hosono, R. (1993). The C. elegans unc-18 gene encodes a protein expressed in motor neurons.
Neuron 11: 703-711.

Hosono, R., Hekimi, S., Kamiya, Y., Sassa, T., Murakami, S., Nishiwaki, K., Miwa, J., Taketo, A. and  Kodaira, K.-I. (1992). The unc-18 gene encodes a novel protein affecting the kinetics of acetylcholine metabolism in the nematode Caenorhabditis elegans.
J. Neurochem. 58: 1517-1525.

Tabuse, Y., Nishiwaki, K. and Miwa, J. (1989). Mutations in a protein kinase C homolog confer phorbol ester resistance on Caenorhabditis elegans.
Science 243: 1713-1716 .

Reviews

Kim, H.-S.and Nishiwaki, K. (2015). Control of the basement membrane and cell migration by ADAMTS proteinases: Lessons from C. elegans genetics.
Matrix Biol. 44-46C:64-69.　

Shibata, Y. and Nishiwaki, K. (2014) Maintenance of cell fates through acetylated histone and the histone variant H2A.z in C. elegans.
Worm 3 　

金憲誠、西脇清二 (2014). 器官形成を導く先端細胞での細胞骨格制御機構　生体の科学　65: 249-254.　

西脇清二 (2014). 分泌型ADAMTSメタロプロテアーゼによる基底膜と細胞移動の制御　細胞工学　33: 613-617.

Kim, H.-S. and Nishiwaki, K. (2012). Nuclear positioning in the gonadal distal tip cells of C.elegans.
Worm 1: 112-115　

菊地哲宏、久保田幸彦、伊原伸治、西脇清二 (2010). 線虫ADAMTSの細胞移動における役割　生化学　82: 957-962.

伊原伸治、西脇清二 (2007). プロドメインがADAMTSプロテアーゼの組織局在に必須である　実験医学　25: 2891-2894.

久保田幸彦、西脇清二 (2007). 分泌型ADAMTSプロテアーゼによる器官形成の制御　細胞工学　26: 1136-1141.

西脇清二 (2007). 特集「細胞外環境による形態形成の制御―新しい生物学の胎動」細胞工学１０月号　監修

Kubota, Y. and Nishiwaki, K. (2006). C.elegans as a model system to study the function of the COG complex in animal development.
Biological Chemistry. 387: 1031-1035.

久保田幸彦、西脇清二 (2004). ADAMプロテアーゼの糖鎖修飾が器官形成に必須の役割を果たす　実験医学 22: 31-37.

西脇清二 (2001). 分泌型ADAMファミリーによる細胞移動と形態形成の制御　実験医学 19: 458-462.

西脇清二、久本直毅、松本邦弘 (2000). ADAMプロテアーゼによる細胞移動の制御　実験医学 18:1825-1827.

西脇清二、三輪錠司 (1991). 線虫Caenorhabditis elegansの母性発現遺伝子　細胞工学10: 17-22.

三輪錠司、西脇清二 (1989). 線虫Caenorhabditis elegansの発生遺伝学　蛋白質核酸酵素 34: 304-314.

Books


Nishiwaki, K. and Kubota, Y. (2007). Role of the basement membrane in cell migration. In “Principles of Developmental Genetics”
(Sally A. Moody, ed.), pp. 404-423, Academic Press.

西脇清二 (2003). 発生過程で起こる細胞移動　（飯野雄一、石井直明編　線虫‐究極のモデル生物‐）　シュプリンガー・フェアラーク東京　57-64.

西脇清二 (2003). 発生解析　（三谷昌平編　線虫ラボマニュアル）　シュプリンガー・フェアラーク東京　175-186.