- 【原著論文】
- ‣K. Warita, T. Warita, C. Beckwitt, M. E. Schurdak, A. Vazquez, A. Wells,
Z. N. Oltvai：Stain-induced mevalonate pathway inhibition attenuates the
growth of mesenchymal-like cancer cells that lack functional E-cadherin
mediated cell cohesion. Sientific Reports,4,7593,2014
- ・ Araki K, Kawauchi K, Sugimoto W, Tsuda D, Oda H, Yoshida R, Ohtani K.:
Mitochondrial protein E2F3d, a distinctive E2F3 product, mediates hypoxia-induced
mitophagy in cancer cells. Commun Biol. 2, 3, 2019.
- ・ Komori H, Goto Y, Kurayoshi K, Ozono E, Iwanaga R, Bradford P, Araki
K and Ohtani K: Differential requirement for dimerization partner DP between
E2F-dependent activation of tumor suppressor and growth-related genes.
Scientific Reports, 8, 8438, 2018.
- ・ Kurayoshi K, Shiromoto A, Ozono E, Iwanaga R, Bradford AP, Araki K, Ohtani
K: Ectopic expression of CDK inhibitor p21Cip1 upregulates deregulated
E2F activity and enhances cancer cell-specific cytotoxic gene expression
mediated by ARF tumor suppressor promoter. Biochem Biophys Res Commun,
483, 107-114, 2017.
- ・ Kurayoshi K, Okuno J, Ozono E, Iwanaga R, Bradford AP, Kugawa K, Araki
K, Ohtani K: The phosphatidyl inositol 3 kinase pathway does not suppress
activation of the ARF and BIM genes by deregulated E2F1 activity. Biochem
Biophys Res Commun, 482, 784-790, 2017.
- ・ Okuda M, Araki K, Ohtani K, Nishimura Y: The interaction mode of the
acidic region of the cell cycle transcription factor DP1 with TFIIH. J
Mol Biol, 428, 4993-5006, 2016.
- ・ Kitamura H, Ozono E, Iwanaga R, Bradford AP, Okuno J, Shimizu E, Kurayoshi
K, Kugawa K, Toh H, Ohtani K.: Identification of novel target genes specifically
activated by deregulated E2F in human normal fibroblasts. Genes Cells,
20, 739-757, 2015
- ・ Kurayoshi K, Ozono E, Iwanaga R, Bradford AP, Komori H, Ohtani K: Cancer
cell specific cytotoxic gene expression mediated by ARF tumor suppressor
promoter constructs. Biochem Biophys Res Commun, 450, 240-246, 2014.
- ・ Moor K, Ohtani K, Myrzakozha D, Zhanserkenova O, Andriana BB, Sato H:
Noninvasive and label-free determination of virus infected cells by Raman
spectroscopy. J Biomed Opt, 19, 67003, 2014.
- ・ Ozono E, Komori H, Iwanaga R, Tanaka T, Sakae T, Kitamura H, Yamaoka
S, Ohtani K: Tumor suppressor TAp73 gene specifically responds to deregulated
E2F activity in human normal fibroblasts. Genes Cells, 17, 660-672, 2012.
- ・ Ma T, Yamada S, Ichwan S, Iseki S, Ohtani K, Otsu M, Ikeda MA: Inability
of p53-reactivating compounds Nutlin-3 and RITA to overcome p53 resistance
in tumor cells deficient in p53Ser46 phosphorylation. Biochem Biophys Res
Commun, 417, 931-937, 2012.
- ・ Ohno Y, Yasunaga S, Ohtsubo M, Mori S, Tsumura M, Okada S, Ohta T, Ohtani,
K, Kobayashi M, and Takihara Y: Hoxb4 transduction down-regulates Geminin
protein, providing hematopoietic stem and progenitor cells with proliferation
potential. Proc Natl Acad Sci USA, 107, 21529-21534, 2010.
- ・ Ozono E, Komori H, Iwanaga R, Ikeda MA, Iseki S, Ohtani K: E2F-like elements
in p27Kip1 promoter specifically sense deregulated E2F activity. Genes
Cells, 14, 89-99, 2009・ Iwanaga R, Ozono E, Fujisawa J, Ikeda MA, Okamura
N, Huang Y, Ohtani, K: Activation of the cyclin D2 and cdk6 genes through
NF-kB is critical for cell cycle progression induced by HTLV-I Tax. Oncogene,
27, 5635-5642, 2008
- ・ Hara T, Matsumura-Arioka Y, Ohtani K, Nakamura M: A role of human T-cell
leukemia virus type I Tax in expression of the human telomerase reverse
transcriptase gene in human T cells. Cancer Science, 99, 1155-1163, 2008
- ・ Gohda J, Irisawa M, Tanaka Y, Sato S, Ohtani K, Fujisawa J, Inoue J:
HTLV-1 Tax-induced NF-kB activation is independent of Lys-63-linked-type
polyubiquitination. Biochem Biophys Res Commun, 357, 225-230, 2007.
- ・ Masai H, Taniyama C, Ogino K, Matsui E, Kakusho N, Matsumoto S, Kim,
JM, Ishii A, Tanaka T, Kobayashi T, Tamai K, Ohtani K, Arai K: Phosphorylation
of MCM4 by Cdc7 kinase facilitates its interaction with Cdc45 on the chromatin.
J Biol Chem, 281, 39249-39261, 2006.
- ・ Goto Y, Hayashi R, Muramatsu T, Ogawa H, Eguchi I, Oshida Y, Ohtani K,
Yoshida K: JPO1/CDCA7, a novel transcription factor E2F1-induced protein,
possesses intrinsic transcriptional regulator activity. Biochim Biophys
Acta, 1759, 60-68, 2006.
- ・ Iwanaga R, Komori H, Ishida S, Okamura N, Nakayama K, Nakayama K-I. Ohtani,
K: Identification of novel E2F1 target genes regulated in cell cycle-dependent
and independent manners. Oncogene, 25, 1786-1798, 2006.
- ・ Komori H, Enomoto M, Nakamura M, Iwanaga R, Ohtani K: Distinct E2F-mediated
transcriptional program regulates p14ARF gene expression. EMBO J, 24, 3724-3736,
2005.
- ・ Matsumura-Arioka Y, Ohtani K, Hara T, Iwanaga R, Nakamura M: Identification
of two distinct elements mediating activation of telomerase (hTERT) gene
expression in association with cell growth in human T cells. Int Immunol,
17, 207-215, 2005.
- ・ Iwanaga R, Komori H, Ohtani K: Differential regulation of expression
of the mammalian DNA repair genes by growth stimulation. Oncogene, 23,
8581-8590, 2004.
- ・ Yamada M, Sato N, Taniyama C, Ohtani K, Arai KI, Masai H: A 63-base pair
DNA segment containing an Sp1 site but not a canonical E2F site can confer
growth-dependent and E2F-mediated transcriptional stimulation of the human
ASK gene encoding the regulatory subunit for human Cdc7-related kinase.
J. Biol. Chem., 277, 27668-27681, 2002.
- ・ Funato N, Ohtani K, Ohyama K, Kuroda T, Nakamura M: Common regulation
of growth arrest and differentiation of osteoblasts by helix-loop-helix
factors. Mol Cell Biol, 21, 7416-7428, 2001.
- ・ Iwanaga R, Ohtani K＊, Hayashi T, Nakamura M: Molecular mechanism of cell
cycle progression induced by the oncogene product Tax of human T-cell leukemia
virus type I. Oncogene, 20, 2055-2067, 2001. (＊Corresponding author)
- ・ Huang Y, Ohtani K＊, Iwanaga R, Matsumura Y, Nakamura M: Direct trans-activation
of the human cyclin D2 gene by the oncogene product Tax of human T-cell
leukemia virus type I. Oncogene, 20, 1094-1102, 2001. (＊Corresponding author)
- ・ Iwanaga R, Ohtani K＊, Nakamura M: Requirement of cell growth for gene
expression induced by the lactose and tetracycline repressor-operator combination
system in a human T cell line. Biochem Biophys Res Commun, 276, 546-552,
2000. (＊Corresponding author)
- ・ Chida T, Okamura N, Ohtani K, Yoshida Y, Arakawa E, Watanabe H: The complete
DNA sequence of the O antigen gene region of Plesiomonas shigelloides serotype
O17 which is identical to Shigella sonnei form I antigen. Microbiol Immunol,
44, 161-172, 2000.
- ・ Ohtani K, Iwanaga R, Arai M, Huang Y, Matsumura Y, Nakamura M: Cell type-specific
E2F activation and cell cycle progression by the oncogene product Tax of
human T-cell leukemia virus type I. J. Biol. Chem., 275, 11154-11163, 2000.
- ・ Arata Y, Fujita M, Ohtani K, Kijima S, Kato J: Cdk2-dependent and -independent
pathways in E2F-mediated S phase induction. J. Biol. Chem., 257, 6337-6345,
2000.
- ・ Tsukahara T, Kannagi M, Ohashi T, Kato H, Arai M, Nunez G, Iwanaga Y,
Yamamoto N, Ohtani K, Nakamura M, Fujii M: Induction of bcl-xL expression
by human T-cell leukemia virus type 1 Tax through NF-kB in apoptosis-resistant
T-cell transfectants with Tax. J. Virol., 73, 7981-7987, 1999
- ・ Iwanaga Y, Tsukahara T, Ohashi T, Tanaka Y, Arai M, Nakamura M, Ohtani
K, Koya Y, Kannagi M, Yamamoto N, Fujii M: Human T-cell leukemia virus
type I Tax protein abrogates interleukin-2 dependence in a mouse T-cell
line. J. Virol., 73, 1271-1277, 1999
- ・ Ohtani K, Iwanaga R, Nakamura M, Ikeda M, Yabuta N, Tsuruga H, Nojima
H: Cell growth-regulated expression of mammalian MCM5 and MCM6 genes mediated
by the transcription factor E2F. Oncogene, 18, 2299-2309, 1999.
- ・ Ohtani K, Tsujimoto A, Ikeda M, Nakamura, M: Regulation of cell growth-dependent
expression of mammalian CDC6 gene by the cell cycle transcription factor
E2F. Oncogene, 17, 1777-1785, 1998.
- ・ Ohtani K, Tsujimoto A, Tsukahara T, Numata N, Miura S, Sugamura K, Nakamura
M: Molecular mechanisms of promoter regulation of the gp34 gene that is
trans-activated by an oncoprotein Tax of human T cell leukemia virus type
I. J Biol Chem, 273, 14119-14129, 1998.
- ・ Sears R, Ohtani K, Nevins JR: Identification of positively and negatively
acting elements regulating the expression of the E2F2 gene in response
to cell growth signals. Mol Cell Biol, 17, 5227-5235, 1997.
- ・ Ohtani K, DeGregori J, Leone G, Herendeen DR, Kelly TJ, Nevins JR: Expression
of the HsOrc1 gene, a human ORC1 homolog, is regulated by cell proliferation
via the E2F transcription factor. Mol Cell Biol, 16, 6977-6984, 1996.
- ・ DeGregori J, Leone G, Ohtani K, Miron A, Nevins JR: E2F-1 accumulation
bypasses a G1 arrest resulting from the inhibition of G1 cyclin-dependent
kinase activity. Genes & Dev, 9, 2873-2887, 1995.
- ・ Ohtani K, DeGregori J, Nevins JR: Regulation of the cyclin E gene by
the E2F1 transcription factor. Proc Natl Acad Sci USA, 92, 12146-12150,
1995.
- ・ Johnson DG, Ohtani K, Nevins JR: Autoregulatory control of E2F1 expression
in response to positive and negative regulators of cell cycle progression.
Genes & Dev, 8, 1514-1525, 1994.
- ・ Ohtani K, Nevins, JR: Functional properties of a Drosophila homolog of
the E2F1 gene. Mol Cell Biol, 14, 1603-1612, 1994.
- ・ Tanaka N, Asao H, Ohtani K, Nakamura M, Sugamura K: A novel human tyrosine
kinase gene inducible in T cells by interleukin 2. FEBS Letters, 324, 1-5,
1993.
- ・ Takeshita T, Asao H, Ohtani K, Ishii N, Kumaki S, Tanaka N, Munakata
H, Nakamura M, Sugamura K: Cloning of the g chain of the human IL-2 receptor.
Science, 257, 379-382, 1992.
- ・ Niki M, Ohtani K, Nakamura M, Sugamura K: Multistep regulation of enhancer
activity of the 21-base-pair element of human T-cell leukemia virus type
I. J. Virol., 66, 4348-4357, 1992. ・ Nagata K, Ide T, Takagi T, Ohtani
K, Aoshima M, Tozawa H, Nakamura M, Sugamura K: Complex formation of human
T-cell leukemia virus type I p40tax transactivator with cellular polypeptides.
J. Virol., 66, 1040-1049, 1992.
- ・ Takeshita T, Ohtani K, Asao H, Kumaki S, Nakamura M, Sugamura K: An associated
molecule, p64, with IL-2 receptor b chain; Its possible role in the formation
of the functional intermediate-affinity IL-2 receptor complex. J Immunol,
148, 2154-2158, 1992.
- ・ Numata N, Ohtani K, Niki M, Nakamura M, Sugamura K: Synergism between
two distinct elements of the HTLV-I enhancer during activation by the trans-activator
of HTLV-I. New Biologist, 9, 1-7, 1991.
- ・ Miura S, Ohtani K, Numata N, Niki M, Ohbo K, Ina Y, Gojobori T, Tanaka
Y, Tozawa H, Nakamura M, Sugamura K: Molecular cloning and characterization
of a novel glycoprotein gp34 that is specifically induced by the human
T-cell leukemia virus type I transactivator p40tax. Mol Cell Biol, 11,
1313-1315, 1991.
- ・Nakamura M, Niki M, Nagata K, Ohtani K, Saito S, Hinuma Y, Sugamura K:
Cell line-dependent response of the enhancer element of simian virus 40
to transactivator p40tax encoded by human T-cell leukemia virus type I.
J. Biol. Chem., 264, 20189-20192, 1989.
- ・Saito S, Ando Y, Furuki K, Kakimoto K, Tanigawa T, Moriyama I, Ichijo
M, Nakamura M, Ohtani K, Sugamura K: Detection of HTLV-I genome in seronegative
infants born to HTLV-I seropositive mothers by polymerase chain reaction.
Jpn J Cancer Res, 80, 808-812, 1989.
- ・Nakamura M, Niki M, Ohtani K, Sugamura K: Differential activation of the
21-base-pair enhancer element of human T-cell leukemia virus type I by
its own trans-activator and cyclic AMP. Nucleic Acids Res, 17, 5207-5221,
1989.
- ・Nagata K, Ohtani K, Nakamura M, Sugamura K: Activation of endogenous c-fos
proto-oncogene expression by human T-cell leukemia virus type I-encoded
p40tax protein in a human T-cell line Jurkat. J. Virol., 63, 3220-3226,
1989.
- ・Ohtani K, Nakamura M, Saito S, Nagata K, Sugamura K, Hinuma Y: Electroporation:
application to human lymphoid cell lines for stable introduction of a transactivator
gene of human T-cell leukemia virus type I. Nucleic Acids Res, 17, 1589-1604,
1989.
- ・Masuda T, Kannagi M, Nakamura M, Ohtani K, Hinuma Y, Harada S: Emergence
of large plaque-producing clones of human immunodeficiency virus (HIV)
in vitro. J. Med. Virol., 27, 170-177, 1989.
- ・Nakamura M, Ohtani K, Hinuma Y, Sugamura K: Functional mapping of the
R region in the HTLV-I long terminal repeat to increase gene expression.
Virus Genes, 2, 147-155, 1988.
- ・Saito S, Nakamura M, Ohtani K, Ichijo M, Sugamura K, Hinuma Y: trans-Activation
of the simian virus 40 enhancer by a pX product of human T-cell leukemia
virus type I. J Virol, 62, 644-648, 1988.
- ・Fujii M, Nakamura M, Ohtani K, Sugamura K, Hinuma Y: 12-O-tetradecanoylphorbol-13-acetate
induces the enhancer function of human T-cell leukemia virus type I. FEBS
Letters, 2, 299-303, 1987.
- ・Ohtani K, Nakamura M, Saito S, Noda T, Ito Y, Sugamura K, Hinuma Y: Identification
of two distinct elements in the long terminal repeat of HTLV-I responsible
for maximum gene expression. EMBO J., 6, 389-395, 1987.
- ・Tamate E, Sasaki T, Muryoi T, Takai O, Otani, K, Tada K, Yoshinaga K:
Expression of idiotype on the surface of human B cells producing anti-DNA
antibody. J Immunol, 136, 1241-1246, 1986.
- 【著書】
- ・Ozono E, Yamaoka S, Ohtani K: To grow, stop or die? - Novel tumor-suppressive
mechanism regulated by the transcription factor E2F. in "Future
Aspects of Tumor Suppressor Gene", Yue Cheng ed., InTech Open
Access Publisher, pp17-43, 2013.4.10
- ・Ichwan S, Bakhtiar MT, Ohtani K, Ikeda MA: Therapeutic targeting of p53-mediated
apoptosis pathway in head and neck squamous cell carcinomas: Current progress
and challenges. in “Tumor Suppressor Genes”, Yue Cheng ed., InTech Open
Access Publisher, pp129-144, 2012.2.4
- ・Ohtani K, Komori H, Ozono E, Ikeda MA, Iwanaga R: Distinct transcriptional
regulation by E2F in cell growth and tumor suppression. in "Control
of Cellular Physiology by the Transcription Factor E2F", Yoshida,
K. ed., Research Signpost, pp91-105. 2008
- ・Ohtani K, Nakamura M: Molecular mechanism of Tax-mediated cell growth
of human T lymphocytes. Gann Monograph on Cancer Research, 50, 43-60, 2003.
- ・大谷清: RB, p53と細胞増殖制御. 新女性医学大系 41巻、武谷雄二ら編、中山書店、 2001; 43-58.
- ・Nakamura M, Ohtani K, Sugamura K, Hinuma Y: Regulation of the promoter
activity of human T-cell leukemia virus type I. In "Gene transfer
and gene therapy", Verma I, Mulligan R and Beauset A eds., Alan
R. Liss, Inc., pp103-116, 1989.
- ・Sugamura K, Ohtani K, Nagata K, Nakamura M: Molecular aspects of human
retrovirus-induced oncogenesis. In "Current topics in medical
virology", Chan YC, Doraisingham S and Ling AE eds., World Scientific,
pp117-134, 1989.
- 【総説】
- ・ 荒木啓吾、大谷清：がん細胞におけるE2Fファミリーの新たな役割 –新規メンバーE2F3dによるミトコンドリア品質管理機構-、生化学、第91巻、第6号、pp.781-784
(2019)
- ・Ozono E, Bradford AP, Iwanaga R, Kurayoshi K, Araki K, Ohtani K: Deregulated
E2F activity: Novel targets and therapeutic potential in cancer treatment.
International Biology Review, No.3, 2016 (KEI Journals)
- ・大谷清、大園瑛子：染色体DNAの複製と安定性を司るRB/E2F. 蛋白質
- ・核酸・酵素, 54, 327-333, 2009
- ・岩永律子、大谷清: HTLV-I Taxによる細胞周期の撹乱. 実験医学 Vol. 21, No.5 （増刊）732-738, 2003
- ・大谷清: DNA複製因子の発現制御. 実験医学、Vol.18, No.7 （増刊）975-981, 2000
- ・Ohtani K: Implication of transcription factor E2F in regulation of DNA
replication. Front Biosci, 4, d793-804, 1999.
- ・大谷清、中村正孝: ゲノムライブラリーとcDNAライブラリーの作成法. 臨床免疫、Vol. 29 (Suppl. 17), 387-399,
1997
- ・Nakamura M, Takasawa N, Ohbo K, Higashimura N, Ohtani K, Tanaka Y, Sugamura
K: HTLV-I Tax trans-activation and cell growth signaling. Leukemia, 11,
7-9, 1997.
- ・大谷清、池田正明: 転写因子E2Fと細胞増殖制御. 蛋白質核酸酵素、Vol.42, No.10 （増刊）1603-1611, 1997
- ・大谷清: E2Fによる細胞周期の制御. 実験医学、Vol.13, No.14 （増刊）1690-1695, 1995・Sugamura K,
Takeshita T, Asao H, Kumaki S, Ohbo K, Ohtani K, Nakamura M: The IL-2/IL-2
receptor system: involvement of a novel receptor subunit, g chain, in growth
signal transduction. Tohoku J Exp Med, 168, 231-237, 1992.
- ・大谷清、中村正孝: p40taxの標的細胞遺伝子. 実験医学、Vol.9, No.16 （増刊） 1959-1966, 1991
- ・ Sugamura K, Takeshita T, Asao H, Kumaki S, Ohbo K, Ohtani K, Nakamura
M: IL-2-induced signal transduction: Involvement of tyrosine kinase and
IL-2 receptor g chain. Lymphokine Research, 9, 539-542, 1990.
- ・菅村和夫、竹下敏一、永田欣也、後藤祐之、浅尾裕信、大谷清、中村正孝、日沼頼夫： T細胞腫瘍化機構におけるHTLV-Iの役割. 腫瘍とウイルス
16, 16-20, 1988