原著論文発表

*: co-first,  #: 責任著者
三宅 の Google Scholar の ページ はこちら
学会発表・日本語記事/総説などはこちら
  1. Miyake, T.#, Doi, M. Intracrine Androgen Metabolism in the Meibomian Gland: Regulation, Circadian Control, and Implications in Dry Eye Disease. Endocrine Journal, 2026. 73:1003–15. https://doi.org/10.1507/endocrj.EJ26-0148 表紙に選ばれました！
  2. Miyake, T.# Roles of Temperature and Reactive Oxygen Species in Circadian Rhythms and Thermosensitivity. Biological and Pharmaceutical Bulletin, 2026. 49:618–24. https://doi.org/10.1248/bpb.b25-00811 【日本薬学会奨励賞 受賞記念総説】

    3. （これより下は関西学院大学着任以前の三宅の論文）

  3. Otani, T.*, Miyake, T.*, Ota, T.*, Yarimizu, D., Nakagawa, Y., Murai, I., Okamura, H., Hasegawa, E., Doi, M. Identification of angiotensin II-responsive circadian clock gene expression in adrenal zona glomerulosa cells and human adrenocortical H295R cells. Frontiers in Endocrinology, 2025. 16:1525844. https://doi.org/10.3389/fendo.2025.1525844
  4. Nguyen Pham, K. T., Miyake, T., Suzuki, T., Kinoshita, S., Hamada, Y., Uehara, H., Machida, M., Nakajima, T., Hasegawa, E., Doi, M. Identification of meibomian gland testosterone metabolites produced by tissue-intrinsic intracrine deactivation activity. iScience, 2025. 28:111808. https://doi.org/10.1016/j.isci.2025.111808
  5. Miyake, T.#,*, Tanaka, K.*, Inoue, Y.*, Nagai, Y., Nishimura, R., Seta, T., Nakagawa, S., Inoue, K-i., Hasegawa, E., Minamimoto, T., Doi, M.# Size-reduced DREADD derivatives for AAV-assisted multimodal chemogenetic control of neuronal activity and behavior. Cell Reports Methods, 2024. 4:100881. https://doi.org/10.1016/j.crmeth.2024.100881 【京都大プレス】
  6. Tomuro, K., Mito, M., Toh, H., Kawamoto, N., Miyake, T., Chow, S.Y.A., Doi, M., Ikeuchi, Y., Shichino, Y., Iwasaki, S. Calibrated ribosome profiling assesses the dynamics of ribosomal flux on transcripts. Nature Communications, 2024. 15:7061. https://doi.org/10.1038/s41467-024-51258-0
  7. Fujita, Y.*, Miyake, T.#,*, Shao, X., Aoki, Y., Hasegawa, E., Doi, M.# Omeprazole induces CYP3A4 mRNA expression but not CYP3A4 protein expression in HepaRG cells. Biological and Pharmaceutical Bulletin, 2024. 47:1218–23. https://doi.org/10.1248/bpb.b24-00161 Editor's pick に選ばれました！
  8. Miyake, T., Inoue, Y., Maekawa, Y., Doi, M. Circadian Clock and Body Temperature. Advances in Experimental Medicine and Biology, 2024, 1461:177–88. https://doi.org/10.1007/978-981-97-4584-5_12
  9. Shao, X.*, Miyake, T.#,*, Inoue, Y., Hasegawa, E., Doi, M.# Temperature-dependent upregulation of Per2 protein expression is mediated by eIF2α kinases PERK and PKR through PI3K activation. Biological and Pharmaceutical Bulletin, 2024. 47:600–5. https://doi.org/10.1248/bpb.b23-00739
  10. Miyake, T.*, Inoue, Y.*, Shao, X., Seta, T., Aoki, Y., Nguyen Pham, K.T., Shichino, Y., Sasaki, J., Sasaki, T., Ikawa, M., Yamaguchi, Y., Okamura, H., Iwasaki, S., Doi, M. Minimal upstream open reading frame of Per2 mediates phase fitness of the circadian clock to day/night physiological body temperature rhythm. Cell Reports, 2023. 42:112157. https://doi.org/10.1016/j.celrep.2023.112157 【京都大プレス】
  11. Hamada, Y., Sasaki, L., Uehara, H., Suzuki, T., Kinoshita, S., Otsuka, K., Kihara, A., Yamaguchi, Y., Miyake, T., Doi, M. Optimising the method for visualising mouse meibomian gland using eyelid whole-mount lipid staining. Ocular Surface, 2022. 26:268–70. https://doi.org/10.1016/j.jtos.2022.10.002
  12. Yamaguchi, Y., Murai, I., Takeda, M., Doi, S., Seta, T., Hanada, R., Kangawa, K., Okamura, H., Miyake, T., Doi, M. Nmu/Nms/Gpr176 triple-deficient mice show enhanced light-resetting of circadian locomotor activity. Biological and Pharmaceutical Bulletin, 2022. 45:1172–9. https://doi.org/10.1248/bpb.b22-00260
  13. Sasaki, L., Hamada, Y., Yarimizu, D., Suzuki, T., Nakamura, H., Shimada, A., Nguyen Pham, K.T., Shao, X., Yamamura, K., Inatomi, T., Morinaga, H., Nishimura, E.K., Kudo, F., Manabe, I., Haraguchi, S., Sugiura, Y., Suematsu, M., Kinoshita, S., Machida, M., Nakajima, T., Kiyonari, H., Okamura, H., Yamaguchi, Y., Miyake, T., Doi, M. Intracrine activity involving NAD-dependent circadian steroidogenic activity governs age-associated meibomian gland dysfunction. Nature Aging, 2022. 2:105–14. https://doi.org/10.1038/s43587-021-00167-8
  14. Yamaguchi, Y., Murai, I., Goto, K., Doi, S., Zhou, H., Setsu, G., Shimatani, H., Okamura, H., Miyake, T., Doi, M. Gpr19 is a circadian clock-controlled orphan GPCR with a role in modulating free-running period and light resetting capacity of the circadian clock. Scientific Reports, 2021. 11:22406. https://doi.org/10.1038/s41598-021-01764-8
  15. Tobori, S., Hiyama, H., Miyake, T., Yano, Y., Nagayasu, K., Shirakawa, H., Nakagawa, T., Mori, Y., Kaneko, S. MrgprB4 in trigeminal neurons expressing TRPA1 modulates unpleasant sensations. Journal of Pharmacological Sciences, 2021. 146:200–5. https://doi.org/10.1016/j.jphs.2021.04.006
  16. Shimatani, H., Inoue, Y., Maekawa, Y., Miyake, T., Yamaguchi, Y., Doi, M. Thermographic imaging of mouse across circadian time reveals body surface temperature elevation associated with non-locomotor body movements. PLoS One, 2021. 16:e0252447. https://doi.org/10.1371/journal.pone.0252447
  17. Wang, T., Nakagawa, S., Miyake, T., Setsu, G., Kunisue, S., Goto, K., Hirasawa, A., Okamura, H., Yamaguchi, Y., Doi, M. Identification and functional characterisation of N-linked glycosylation of the orphan G protein-coupled receptor Gpr176. Scientific Reports, 2020. 10:4429. https://doi.org/10.1038/s41598-020-61370-y
  18. Miyake, T., Doi, M. Reconstitution of Organismal Liver Clock Function Requires Light. Trends in Endocrinology and Metabolism, 2019. 30:569–71. https://doi.org/10.1016/j.tem.2019.07.017
  19. Kawai, H., Asaoka, N., Miyake, T., Nagayasu, K., Nakagawa, T., Shirakawa, H., Kaneko, S. Neurotropin inhibits neuronal activity through potentiation of sustained Kv currents in primary cultured DRG neurons. Journal of Pharmacological Sciences, 2018. 137:313–16. https://doi.org/10.1016/j.jphs.2018.05.005
  20. Ohashi, K., Deyashiki, A., Miyake, T., Nagayasu, K., Shibasaki, K., Shirakawa, H., Kaneko, S. TRPV4 is functionally expressed in oligodendrocyte precursor cells and increases their proliferation. Pflügers Archiv: European Journal of Physiology, 2018. 470:705–16. https://doi.org/10.1007/s00424-018-2130-3
  21. Kuramoto, T., Yokoe, M., Kunisawa, N., Ohashi, K., Miyake, T., Higuchi, Y., Yoshimi, K., Mashimo, T., Tanaka, M., Kuwamura, M., Kaneko, S., Shimizu, S., Serikawa, T., Ohno, Y. Tremor dominant Kyoto (Trdk) rats carry a missense mutation in the gene encoding the SK2 subunit of small-conductance Ca2+-activated K+ channel. Brain Research, 2017. 1676:38–45. https://doi.org/10.1016/j.brainres.2017.09.012
  22. Miyake, T., Nakamura, S., Zhao, M., Hamano, S., Inoue, K., Numata, T., Takahashi, N., Nagayasu, K., Shirakawa, H., Mori, Y., Nakagawa, T., Kaneko, S. Distinct mechanism of cystein oxidation-dependent activation and cold sensitization of human transient receptor potential ankyrin 1 channel by high and low oxaliplatin. Frontiers in Physiology, 2017. 8:878. https://doi.org/10.3389/fphys.2017.00878
  23. Shirakawa, H., Katsumoto, R., Iida, S., Miyake, T., Higuchi, T., Nagashima, T., Nagayasu, K., Nakagawa, T., Kaneko, S. Shingoshine-1-phosphate induces Ca2+ signaling and CXCL1 release via TRPC6 channel in astrocytes. Glia, 2017. 65:1005–16. https://doi.org/10.1002/glia.23141
  24. Miyake, T., Nakamura, S., Zhao, M., So, K., Inoue, K., Numata, T., Takahashi, N., Shirakawa, H., Mori, Y., Nakagawa, T., Kaneko, S. Cold sensitivity of TRPA1 is unveiled by the prolyl hydroxylation blockade-induced sensitization to ROS. Nature Communications, 2016. 7:12840. https://doi.org/10.1038/ncomms12840 【京都大プレス】
  25. So, K., Tei, Y., Zhao, M., Miyake, T., Hiyama, H., Shirakawa, H., Imai, S., Mori, Y., Nakagawa, T., Matsubara, K., Kaneko, S. Hypoxia-induced sensitisation of TRPA1 in painful dysesthesia evoked by transient hindlimb ischemia/reperfusion in mice. Scientific Reports, 2016. 6:23261. https://doi.org/10.1038/srep23261
  26. Miyake, T., Shirakawa, H., Nakagawa, T., Kaneko, S. Activation of mitochondrial transient receptor potential vanilloid 1 channel contributes to microglial migration. Glia, 2015. 63:1870–82. https://doi.org/10.1002/glia.22854
  27. Miyake, T.*, Shirakawa, H.*, Kusano, A.*, Sakimoto, S., Konno, M., Nakagawa, T., Mori, Y., Kaneko, S. TRPM2 contributes to LPS/IFNγ-induced production of nitric oxide via the p38/JNK pathway in microglia. Biochemical and Biophysical Research Communications, 2014. 444:212–7. https://doi.org/10.1016/j.bbrc.2014.01.022
  28. Zhao, M., Nakamura, S., Miyake, T., So, K., Shirakawa, H., Tokuyama, S., Narita, M., Nakagawa, T., Kaneko, S. Pharmacological characterization of standard analgesics on oxaliplatin-induced acute cold hypersensitivity in mice. Journal of Pharmacological Sciences, 2014. 124:514–7. https://doi.org/10.1254/jphs.13249sc
  29. Munakata, M., Shirakawa, H., Nagayasu, K., Miyanohara, J., Miyake, T., Nakagawa, T., Katsuki, H., Kaneko, S. The TRPC3 inhibitor Pyr3 improves outcomes and attenuates astrogliosis after intracerebral hemorrhage in mice. Stroke, 2013. 44:1981–7. https://doi.org/10.1161/strokeaha.113.679332
  30. Konno, M., Shirakawa, H., Iida, S., Sakimoto, S., Matsunami, I., Miyake, T., Kageyama, K., Nakagawa, T., Shibasaki, K., Kaneko, S. Stimulation of transient receptor potential vanilloid 4 channel suppresses abnormal activation of microglia induced by lipopolysaccharide. Glia, 2012. 60:761–70. https://doi.org/10.1002/glia.22306
  31. Konno, M., Shirakawa, H., Miyake, T., Sakimoto, S., Nakagawa, T., Kaneko, S. Calumin, a Ca2+-binding protein on the endoplasmic reticulum, alters the ion permeability of Ca2+ release-activated Ca2+ (CRAC) channels. Biochemical and Biophysical Research Communications, 2012. 417:784–9. https://doi.org/10.1016/j.bbrc.2011.12.035

更新日：2026.09.03