研究成果

原著論文(2013年以前)

2013
[30] "DFT Study on 5-Endo-Trig-Type Cyclization of 3-Alkenoic Acids Using Pd-SPRIX Catalyst: Importance of the Rigid Spiro Framework for Both Selectivity and Reactivity"
Gabr, R. K.; Hatakeyama, T.; Takenaka, K.; Takizawa, S.; Okada, Y.; Nakamura, M.; Sasai, H.
Chem. Eur. J. 2013, 18, 9518-9525. doi
2012
[29] "Iron-Catalyzed Aromatic Amination for Nonsymmetrical Triarylamine Synthesis."
Hatakeyama, T.; Imayoshi, R.; Yoshimoto, Y.; Ghorai, S. K.; Jin, M.; Takaya, H.; Norisue, K.; Sohrin, Y.; Nakamura, M.
J. Am. Chem. Soc. 2012, 134, 20262-20265. doi Highlighted in SYNFACTS, 2013, 9, 0313 (SYNFACT of the Month).
[28] "Azaboradibenzo[6]helicene: Carrier Inversion Induced by Helical Homochirality."
Hatakeyama, T.; Hashimoto, S.; Oba, T.; Nakamura, M.
J. Am. Chem. Soc. 2012, 134, 19600-19603. doi Highlighted in JACS Spotlights, 2013, 135, 1-1. doi Highlighted in SYNFACTS, 2013, 9, 0157.
[27] "Iron Promoted Conjugate Addition: Implication of the Six-Centered Mechanism Based on the Isolation of the Iron-Enolate Intermediate."
Noda, D.; Sunada, Y.; Hatakeyama, T.; Nakamura, M.; Nagashima, H.
Chem. Commun. 2012, 48, 12231-12233. doi
[26] "Iron-Catalyzed Alkyl-Alkyl Suzuki-Miyaura Coupling."
Hatakeyama, T.; Hashimoto, T.; Kathriarachchi, K. K. A. D. S.; Zenmyo T.; Seike, H.; Nakamura, M. Angew. Chem., Int. Ed. 2012, 51, 8834-8837. doi Highlighted in SYNFACTS, 2012, 8, 1237.
Selected as a Hot Paper of Angewandte Chemie.
[25] "Cross-Coupling of Non-activated Chloroalkanes with Aryl Grignard Reagents in the Presence of Iron/N-Heterocyclic Carbene Catalysts."
Ghorai, S. K.; Jin, M.; Hatakeyama, T.; Nakamura, M.
Org. Lett. 2012, 14, 1066-1069. doi
[24] "Stereospecific Cross-Coupling between Alkenylboronates and Alkyl Halides Catalyzed by Iron-Bisphosphine Complexes."
Hashimoto, T.; Hatakeyama, T.; Nakamura, M.
J. Org. Chem. 2012, 77, 1168-1173. doi Highlighted in JACS β, 2012, 77.
2011
[23] "Synthesis of BN-fused Polycyclic Aromatics via Tandem Intramolecular Electrophilic Arene Borylation."
Hatakeyama, T.; Hashimoto, S.; Seki, S.; Nakamura, M.
J. Am. Chem. Soc. 2011, 133, 18614-18617. doi Highlighted in SYNFACTS, 2012, 8, 0159.
[22] "Kumada-Tamao-Corriu Coupling of Alkyl Halides Catalyzed by an Iron-Bisphosphine Complex."
Hatakeyama, T.; Fujiwara, Y.; Okada, Y.; Itoh, T.; Hashimoto, T.; Kawamura, S.; Ogata, K.; Takaya, H.; Nakamura, M.
Chem. Lett. 2011, 40, 1030-1032. doi
[21] "Tuning Chemoselectivity in Iron-Catalyzed Sonogashira-type Reaction Using a Bisphosphine Ligand with Peripheral Steric Bulk: Selective Alkynylation of Non-activated Alkyl Halides."
Hatakeyama, T.; Okada, Y.; Yoshimoto, Y.; Nakamura, M.
Angew. Chem., Int. Ed. 2011, 50, 10973-10976. doi (back cover picture doi) Highlighted in SYNFORM, 2012, A14. Highlighted in SYNFACTS, 2012, 8, 0193 (SYNFACT of the Month).
[20] "Tandem Phospha-Friedel-Crafts Reaction Toward Curved π-Conjugated Frameworks with a Phosphorus Ring Junction."
Hatakeyama, T.; Hashimoto, S.; Nakamura, M.
Org. Lett. 2011, 13, 2130-2133. doi
2010
[19] "Nickel-Catalyzed Alkenylative Cross-Coupling Reaction of Alkyl Sulfides."
Ishizuka, K.; Seike, H.; Hatakeyama, T.; Nakamura, M.
J. Am. Chem. Soc. 2010, 132, 13117-13119. doi Highlighted in SYNFACTS, 2010, 1402.
[18] "Iron-Catalyzed Suzuki-Miyaura Coupling of Alkyl Halides."
Hatakeyama, T.; Hashimoto, T.; Kondo, Y.; Fujiwara, Y.; Seike, H.; Takaya, H.; Tamada, Y.; Ono, T.; Nakamura, M.
J. Am. Chem. Soc. 2010, 132, 10674-10676. doi Highlighted in SYNFACTS, 2010, 1290.
[17] "Transition-Metal-Free Electrophilic Amination between Aryl Grignard Reagents and N-Chloroamines."
Hatakeyama, T.; Yoshimoto, Y.; Ghorai, S. K.; Nakamura, M.
Org. Lett. 2010, 12, 1516-1519. doi Highlighted in SYNFACTS, 2010, 0821.
2009
[16] "Laterally mobile, functionalized self-assembled monolayers at the fluorous-aqueous interface in a plug based microfluidic system: characterization and testing with membrane protein crystallization"
Kreutz, J.; Li, L.; Roach, S.; Hatakeyama, T.; Ismagilov, R. F.
J. Am. Chem. Soc. 2009, 131, 6042-6043.
[15] "Iron-Catalyzed Negishi Coupling Toward an Effective Olefin Synthesis."
Hatakeyama, T.; Nakagawa, N.; Nakamura, M.
Org. Lett.2009, 11, 4496-4499. doi Highlighted in SYNFACTS, 2010, 0089.
[14] "Highly Selective Biaryl Cross-Coupling Reactions between Aryl Halides and Aryl Grignard Reagents: A New Catalyst Combination of N-Heterocyclic Carbenes and Iron, Cobalt, and Nickel Fluorides."
Hatakeyama, T.; Hashimoto, S.; Ishizuka, K.; Nakamura, M.
J. Am. Chem. Soc. 2009, 131, 11949-11963. doi Highlighted in SYNFACTS, 2009, 11, 1268.
[13] "Effect of TMEDA on Iron-Catalyzed Coupling Reactions of ArMgX with Alkyl Halides."
Noda, D.; Sunada, Y.; Hatakeyama, T.; Nakamura, M.; Nagashima, H.
J. Am. Chem. Soc. 2009, 131, 6078-6079. doi Highlighted in SYNFACTS, 2009, 0751.
[12] "Iron-Catalysed Fluoroaromatic Coupling Reactions under Catalytic Modulation with 1,2-Bis(diphenylphosphino)benzene"
Hatakeyama, T.; Kondo, Y.; Fujiwara, Y.; Takaya, H.; Ito, S.; Nakamura, E.; Nakamura, M.
Chem. Comm. 2009, 1216-1218. doi Selected as a Hot Paper of Chem. Commun. doi

▲ページトップへ

2008
[11] "Iron-Catalyzed Enyne Cross-Coupling Reaction"
Hatakeyama, T.; Yoshimoto, Y; Toma, G.: Nakamura, M.
Org. Lett. 2008, 10, 5541-5544. doi Highlighted in SYNFACTS, 2009, 0317.
[10] "Diastereoselective Addition of Zincated Hydrazones to Alkenylboronates and Stereospecific Trapping of Boron/Zinc Bimetallic Intermediates by Carbon Electrophiles"
Hatakeyama, T.; Nakamura, M.; Nakamura, E.
J. Am. Chem. Soc. 2008, 130, 15688-15701. doi

▲ページトップへ

2007
[9] "Iron-Catalyzed Selective Biaryl Coupling: Remarkable Suppression of Homocoupling by the Fluoride Anion"
Hatakeyama, T.; Nakamura, M.
J. Am. Chem. Soc. 2007, 129, 9844-9845. doi Highlighted in SYNFACTS, 2007, 1199.
[8] "Regioselective alpha-Alkylation of Ketones with Alkyl Chlorides and Fluorides via Highly Nucleophilic Magnesium Enamides"
Hatakeyama, T.; Ito, S.; Yamane, H.; Nakamura, M.; Nakamura, E.
Tetrahedron 2007, 63, 8440-8448. doi
[7] "Indium-Catalyzed 2-Alkenylation of 1,3-Dicarbonyl Compounds with Unactivated Alkynes"
Endo, K.; Hatakeyama, T.; Nakamura, M.; Nakamura, E.
J. Am. Chem. Soc. 2007, 129, 5264-5271. doi

▲ページトップへ

2006
[6] "Microgram-Scale Testing of Reaction Conditions in Solution Using Nanoliter Plugs in Microfluidics with Detection by MALDI-MS"
Hatakeyama, T.; Chen, D. L.; Ismagilov, R. F.
J. Am. Chem. Soc. 2006, 128, 2518-2519. Highlighted in Nature, 2006, 439, 767.
2005
[5] "Alkylation of Magnesium Enamide with Alkyl Chlorides and Fluorides"
Hatakeyama, T.; Ito, S.; Nakamura, M.; Nakamura,E.
J. Am. Chem. Soc. 2005, 127, 14192-14193. Highlighted in SYNFACTS, 2006, 0057.

▲ページトップへ

2004
[4] "Sequential Coupling of Zincated Hydrazone, Alkenylboronate, and Electrophile that Creates Several Contiguous Stereogenic Centers"
Nakamura, M.; Hatakeyama, T.; Hara, K.; Fukudome, H.; Nakamura, E.
J. Am. Chem. Soc. 2004, 126, 14344-14345.
[3] "alpha-Alkylation of Ketones by Addition of Zinc Enamides to Unactivated Olefins"
Nakamura, M.; Hatakeyama, T.; Nakamura, E.
J. Am. Chem. Soc. 2004, 126, 11820-11825.

▲ページトップへ

2003
[2] "Enantioselective Synthesis of alpha-Substituted Ketones by Asymmetric Addition of Chiral Zinc Enamides to 1-Alkenes"
Nakamura, M.; Hatakeyama, T.; Hara, K.; Nakamura, E.
J. Am. Chem. Soc. 2003, 125, 6362-6363.
[1] "Regioselective Allylzincation of Vinylboronate"
M.; Hara, K.; Hatakeyama, T.; Nakamura, E.
Org.Lett. 2001, 3, 3137-3140.

▲ページトップへ