申請者氏名	Requested Supervising Professor
田辺　陽	Yoo TANABE
研究題目	Title of the project
	Exploitation of efficient, practical, innovative organic reactions directed for process chemistry and its application to the practical syntheses of important fine chemicals and natural products.
博士研究員への要望・専門、経験等	Qualifications for Postdoctoral Fellow including academic and non-academic background, research fields and interests
	1. Knowledge and experiement of organic synthesis for fine chemicals and for organometallics. 2. Measurements of NMR, IR, MASS, HPLC, GLC, etc. 3. Interests in the exploitation of unit organic reactions and its synthetic applications.
研究計画	Details on research project
	Our research focuses on the development of new, original, useful, and practical organic reactions from recent green chemical standpoints and on the application to the short-step syntheses of fine chemicals and natural products. (1) Exploitation of Crossed Ti, Zr-Claisen condensation, related Ti-direct aldol addition, Mannich reactions. Its application of these Ti, and Zr reactions to useful fine chemicals such as musk perfume (Z)-civetone, R-muscone, R-mintlactone, R-menthofuran, cis-jasmone, its lactone analog, etc.) and 1β-methylcarabapenem by practical methods. J. Org. Chem., 53, 1560 (1988); Tetrahedron, 56, 7423 (2000); Chem. Commun., 1674 (2001); Synlett, 1959 (2001); Adv. Synth. Catal., 344, 507 (2002); Tetrahedron (Symposium), 58, 8269 (2002); Chem. Commun., 2542 (2002); Adv. Synth. Catal., 345, 967 (2003); ACS Synposium Series, No. 892, "New Discoveries in Agrochemicals," Chapter 25 (2005); J. Am. Chem. Soc., 127, 2845 (2005); Chem. Commun. 3171 (2005); Synlett, (Special issue) 129 (2006); Org. Process Res. Dev., 10, 500 (2006); Org. Lett., 8, 5215 (2006); Chem. Lett., 48 (2007); Org. Biomol. Chem., 5, 151 (2007); Org. Lett., 9, 1859 (2007); Chem. Commun., 771 (2008); Tetrahedron Lett., 49, 4509 (2008); Adv. Synth. Catal., 352, 1128 (2010). (2) Novel, efficient, and environmentally benign esterification, amide formation, sulfonylation, and silylation. Tetrahedron Lett., 41, 5249 (2000); Angew. Chem. Int. Ed. Highlight [J. Otera, 40, 2044 (2001); Tetrahedron Lett., 42, 7427 (2001); Tetrahedron, 59, 5337 (2003); Adv. Synth. Catal., 345, 1209 (2003); Bull. Chem. Soc. Jpn., 68, 297 (1995); Tetrahedron, 55, 2183 (1999); Synthesis, 1633 (1999); J. Synth. Org. Chem. Jpn., 62, 1248 (2004); Green Chem. Submitted; Chem. Commun., 2478 (2001); Chem. Commun., 1628 (2002); Green Chem., 7, 711 (2005) Hot Article; J. Org. Chem.., 71, 5380 (2006); Adv. Synth. Catal., 348, 2057 (2006); Green Chem. 8, 1022 (2006). Frontcover Article. J. Org. Chem., 72, 4970 (2007); J. Org. Chem., 72, 8142 (2007); Tetrahedron, 50, 12071 (2007); Org. Lett. 10, 2131 (2008). Selected as SYNFACTS; Tetrahedron (Symposium in print), 65, 5596 (2009); Org. Lett., 11, 4258-4261 (2009). (3) Useful organic synthesis based on characteristic properties based on cyclopropanes such as the regiocontrolled benzannulation and the chirality exchange from sp^3 central chirality into axial chirality. Application to total synthesis of natural lignan lactone. J. Synth. Org. Chem. Jpn., 57, 170 (1999); J. Am. Chem. Soc., 126, 5358 (2004); J. Org. Chem., 70, 2667 (2005). Chem. Lett., 62 (2007); Org. Lett., 9, 563 (2007); Org. Biomol. Chem., 6, 540 (2008). (4) Stereostructure-activity relationship of biologically active pharmaceuticals, perfumes, and agrochemicals. Tetrahedron Lett., 32, 379-382 (1991); Biosci. Biotech. Biochem., 59, 1355 (1995); J. Chem. Soc., Perkin Trans. 1, 935 (1995); J. Chem. Soc., Perkin Trans. 1, 1243 (1996); Biosci. Biotech. Biochem., 61, 547 (1997); Bioorg. Med. Chem., 9, 33 (2001). E-mail: tanabe@kwansei.ac.jp Home page: http://sci-tech.ksc.kwansei.ac.jp/~tanabe/index.html
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